2014-今 清华大学 材料学院 副教授

2010-2014 清华大学 工程物理系 副教授

2007-2009 清华大学 工程物理系 助理教授

2004-2006 新加坡国立大学 化学与生物分子系 博士后

本科生：材料化学、有机化学与生物化学、脑疾病的神经科学问题研究与诊疗新实践、科技创新与挑战

研究生：生物材料、生物医用材料，纳米医用材料

部分典型科研项目：

1. AgeTec胶原蛋白肽中活性多肽成分筛选与评价，企事业单位委托项目，2024-2026

2. 可注射多功能空间异构水凝胶微胶囊的批量化制备及在战场伤口愈合的应用研究，企事业单位委托项目，2024-2025

3. 胎盘多肽中促皮肤改善的成分筛选及其作用机制探索，北京市自然科学基金，2023-2026

4. 金属酚醛网络功能化的碳酸钙纳米颗粒诱导肿瘤副凋亡现象的研究，普通项目，2021-2023

5. 交变磁场/pH刺激响应的镓铟液态金属复合介质用于乳腺癌综合治疗研究，面上项目，2020-2023

6. 磁性鸡尾酒功能型水凝胶用于乳腺癌治疗，面上项目，2017-2020

7. 载药纳米复合植入剂用于脑胶质瘤磁感应综合治疗的研究，面上项目，2012-2015

8. 新型材料介导的肿瘤动脉栓塞磁感应热疗，面上项目，2010-2012

部分典型科研论文：

[1] Guo, Z.; Gao, X.; Lu, J.; Li, Y.; Jin, Z.; Fahad, A.; Pambe, N. U.; Ejima, H.; Sun, X.; Wang, X.; Xie, W.; Zhang, G.; Zhao, L*. Apoptosis and Paraptosis Induced by Disulfiram-Loaded Ca²⁺/Cu²⁺ Dual-Ions Nano Trap for Breast Cancer Treatment. ACS Nano 2024, 18 (9), 6975-6989, Article. DOI: 10.1021/acsnano.3c10173.

[2] Xie, W.; Zhang, G.; Guo, Z.; Lu, J.; Ye, J.; Xu, W.; Gao, X.; Yue, K.; Wei, Y.; Zhao, L*. Ultra-Sensitive Iron-Doped Palladium Nanocrystals with Enhanced Hydroxyl Radical Generation for Chemo-/Chemodynamic Nanotherapy. Advanced Functional Materials 2022, 32 (12). DOI: 10.1002/adfm.202107518.

[3] Guo, Z.; Lu, J.; Wang, D.; Xie, W.; Chi, Y.; Xu, J.; Takuya, N.; Zhang, J.; Xu, W.; Gao, F.; Wu, H.; Zhao, L*. Galvanic replacement reaction for in situ fabrication of litchi-shaped heterogeneous liquid metal-Au nano-composite for radio-photothermal cancer therapy. Bioactive Materials 2021, 6 (3), 602-612. DOI: 10.1016/j.bioactmat.2020.08.033.

[4] Lu, J.; Zheng, R.; Shi, Z.; Gao, X.; Li, Y.; Fahad, A.; Ufurahi-Pambe, N.; Jin, Z.; Chen, S.; Xie, W.; Guo, Z.; Yu, J.; Che, S.; Zhang, G.; Xu, B.; Wei, Y.; Zhao, L*. Intracellular Criegee's mechanism-based synergistic ozone therapy mediated by oleogels for cancer treatment. Journal of Controlled Release 2024, 370, 879-890. DOI: 10.1016/j.jconrel.2024.05.039.

[5] Xie, W.; Ye, J.; Guo, Z.; Lu, J.; Xu, W.; Gao, X.; Huang, H.; Hu, R.; Mao, L.; Wei, Y. Zhao, L*. TME-responded Full-biodegradable nanocatalyst for mitochondrial calcium Overload-induced hydroxyl radical bursting cancer treatment. Chemical Engineering Journal 2022, 438, Article. DOI: 10.1016/j.cej.2022.135372.

[6] Guo, Z.; Xie, W.; Zhang, Q.; Lu, J.; Ye, J.; Gao, X.; Xu, W.; Fahad, A.; Xie, Y.; Wei, Y.; Zhao, L*. Photoactivation-triggered in situ self-supplied H₂O₂for boosting chemodynamic therapy via layered double Hydroxide-mediated catalytic cascade reaction. Chemical Engineering Journal 2022, 446. DOI: 10.1016/j.cej.2022.137310.

[7] Xie, W.; Guo, Z.; Gao, F.; Gao, Q.; Wang, D.; Liaw, B.-s.; Cai, Q.; Sun, X.; Wang, X.; Zhao, L*. Shape-, size- and structure-controlled synthesis and biocompatibility of iron oxide nanoparticles for magnetic theranostics. Theranostics 2018, 8 (12), 3284-3307, Review. DOI: 10.7150/thno.25220.

[8] Guo, Z.; Xie, W.; Lu, J.; Guo, X.; Xu, J.; Xu, W.; Chi, Y.; Takuya, N.; Wu, H.; Zhao, L*. Tannic acid-based metal phenolic networks for bio-applications: a review. Journal of Materials Chemistry B 2021, 9 (20), 4098-4110. DOI: 10.1039/d1tb00383f.